2. Signaling Pathways
  3. Anti-infection
    Metabolic Enzyme/Protease
  4. HIV Protease

HIV Protease

HIV Protease

Related Products

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HIV protease, a homodimeric aspartyl protease, is crucial for the viral life-cycle, cleaving proviral polyproteins, hence creating mature protein components that are required for the formation of an infectious virus. HIV protease cleaves newly synthesized polyproteins at the appropriate places to create the mature protein components of an infectious HIV virion. HIV protease is a critical drug target in designing anti-retroviral drugs to treat HIV/AIDS (acquired immune deficiency syndrome).

HIV-1 protease permits viral maturation by processing the Gag and Gag-Pro-Pol polyproteins. It recognizes and cleaves more than 12 different substrates leading to viral maturation. Similar to that of HIV-1, HIV-2 protease is also a homodimeric aspartyl enzyme that plays a vital role in the HIV life-cycle through processing of Gag and Gag-Pro-Pol precursor polyproteins leading to viral maturation.

HIV Protease Related Products (164):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-17367AR
    Atazanavir sulfate (Standard)
    		Inhibitor
    Atazanavir (sulfate) (Standard) is the analytical standard of Atazanavir (sulfate). This product is intended for research and analytical applications. Atazanavir (BMS-232632) sulfate, a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration. Atazanavir sulfate is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp). Atazanavir sulfate is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM.
    Atazanavir sulfate (Standard)
  • HY-B0689B
    Indinavir sulfate ethanolate
    		Inhibitor
    Indinavir sulfate ethanolate (MK-639 ethanolate) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR. Indinavir sulfate ethanolate exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir sulfate ethanolate is also a SARS-CoV 3CLpro inhibitor.
    Indinavir sulfate ethanolate
  • HY-105148
    Mozenavir
    		Inhibitor
    Mozenavir (DMP 450) is an orally active and highly selective inhibitor of HIV-1 protease (Ki=0.3 nM). Mozenavir blocks the cleavage and processing of viral polyproteins, inhibiting the replication and maturation of HIV-1. Mozenavir is promising for research of HIV infection.
    Mozenavir
  • HY-N12716
    Longipedunin A
    		Inhibitor
    Longipedunin A is a HIV-1 Protease inhibitor with an IC50 value of 50 µg/mL.
    Longipedunin A
  • HY-146804
    HIV-1 protease-IN-3
    		Inhibitor
    HIV-1 protease-IN-3 (compound 14) is a potent inhibitor of HIV-1 protease (IC50=71 nM; EC50=0.86 μM).
    HIV-1 protease-IN-3
  • HY-N6773R
    Cytochalasin A (Standard)
    		Inhibitor
    Ketoprofen (lysinate) (Standard) is the analytical standard of Ketoprofen (lysinate). This product is intended for research and analytical applications. Ketoprofen (RP-19583) lysinate is a non-steroidal anti-inflammatory agent. Ketoprofen lysinate can inhibit the activity of cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2). which is potential in the research of inflammation, immunology, and metabolic disease such as obesity.
    Cytochalasin A (Standard)
  • HY-P4543
    HIV-IN petide
    		Inhibitor
    HIV-IN petide is a competitive inhibitor of HIV-1 protease (Ki=50 nM).
    HIV-IN petide
  • HY-155690
    HIV-1 protease-IN-11
    		Inhibitor
    HIV-1 protease-IN-11 (compound 34a) is a HIV-1 protease inhibitor with an IC50 of 0.41 nM. HIV-1 protease-IN-11 also exhibits significant activity against drug-resistant variant.
    HIV-1 protease-IN-11
  • HY-130366
    JG-365
    JG-365 is an HIV-1 protease inhibitor that binds to the active site of HIV-1 protease.
    JG-365
  • HY-136986
    Desthiazolylmethyl ritonavir
    		Control
    Desthiazolylmethyl ritonavir is a base-catalyzed degradation product of the HIV protease inhibitor Ritonavir (HY-90001).
    Desthiazolylmethyl ritonavir
  • HY-15148R
    Tipranavir (Standard)
    		Inhibitor
    Tipranavir (Standard) is the analytical standard of Tipranavir. This product is intended for research and analytical applications. Tipranavir (PNU-140690) inhibits the enzymatic activity and dimerization of HIV-1 protease, exerts potent activity against multi-protease inhibitor (PI)-resistant HIV-1 isolates with IC50s of 66-410 nM. Tipranavir inhibits SARS-CoV-2 3CLpro activity.
    Tipranavir (Standard)
  • HY-17007R
    Saquinavir (Standard)
    		Inhibitor
    Saquinavir (Standard) (Ro 31-8959 (Standard)) is the analytical standard of Saquinavir (HY-17007). This product is intended for research and analytical applications. Saquinavir (Ro 31-8959) is an orally active HIV protease inhibitor that can be used in the research of AIDS. Saquinavir also has anti-inflammatory activity and can induce apoptosis of human red blood cells.
    Saquinavir (Standard)
  • HY-19135
    A-77003
    		Inhibitor
    A-77003 is an inhibitor for HIV protease, with IC50 of 0.1 to 0.2 μg/ml, for HIV-1 and HIV-2 protease. A-77003 exhibits high levels of antiretroviral activity and low cytotoxicity in vitro.
    A-77003
  • HY-129563
    CGP 57813
    		Inhibitor
    CGP 57813 is a peptidomimetic inhibitor of HIV protease that can be encapsulated by nanoparticles composed of poly(D,L-lactic acid) (PLA) and pH-sensitive methacrylic acid copolymers and delivered into the body.
    CGP 57813
  • HY-125571
    A 74704
    		Inhibitor
    A 74704 is a pseudo C2-symmetric inhibitor of HIV-1 protease and its diester analog.
    A 74704
  • HY-W653853
    Ritonavir-13C3
    		Inhibitor
    Ritonavir-13C3 is 13C labeled Ritonavir. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.61 μM.
    Ritonavir-<sup>13</sup>C<sub>3</sub>
  • HY-14588S1
    Lopinavir-d8
    		Inhibitor
    Lopinavir-d8 (ABT-378-d8) is the deuterium labeled Lopinavir. Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with Kis of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity. Lopinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 14.2 μM.
    Lopinavir-d<sub>8</sub>
  • HY-19194
    A-80987
    		Inhibitor
    A-80987 is an inhibitor of human immunodeficiency virus type 1 (HIV-1) protease.
    A-80987
  • HY-N0554R
    Escin IA (Standard)
    		Inhibitor
    Escin IA (Standard) is the analytical standard of Escin IA. This product is intended for research and analytical applications. Escin IA is a triterpene saponin isolated from Aesculus hippocastanum, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression.
    Escin IA (Standard)
  • HY-17040R
    Darunavir (Standard)
    		Inhibitor
    Darunavir (Standard) is the analytical standard of Darunavir. This product is intended for research and analytical applications. Darunavir (TMC114), an orally active next generation HIV protease inhibitor, has a similar antiviral activity against the mutant and the wild-type viruses. Darunavir (TMC114) is potent against laboratory HIV-1 strains and primary clinical isolates (IC50 = 0.003 μM; IC90 = 0.009 μM) with minimal cytotoxicity.
    Darunavir (Standard)